US Patent Issued to The Johns Hopkins University on July 28 for "Albumin-proaerolysin prodrugs" (Maryland Inventors)

ALEXANDRIA, Va., July 28 -- United States Patent no. 12,691,158, issued on July 28, was assigned to The Johns Hopkins University (Baltimore).

"Albumin-proaerolysin prodrugs" was invented by John T. Isaacs (Phoenix, Md.), Samuel R. Denmeade (Ellicott City, Md.) and W. Nathaniel Brennen (Baltimore).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for treating cancer using albumin-proaerolysin prodrugs. Accordingly, in one aspect, the present invention provides prodrug compositions. In certain embodiments, a prodrug composition comprises a prostate-specific antigen (PSA)-activated pro-ae...