US Patent Issued to The Johns Hopkins University on Feb. 10 for "Itraconazole analogs and use thereof" (American, Singaporean Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,545,666, issued on Feb. 10, was assigned to The Johns Hopkins University (Baltimore).

"Itraconazole analogs and use thereof" was invented by Jun O. Liu (Clarksville, Md.), Yingjun Li (Baltimore), Kalyan Kumar Pasunooti (Singapore), Wukun Liu (Baltimore), Wei Shi (Fayetteville, Ark.), Ruojing Li (Baltimore) and Sarah Head (Baltimore).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs."

The patent was filed on April 30,...