US Patent Issued to The Johns Hopkins University on Dec. 16 for "Nanoparticles for drug delivery to brain" (Maryland Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,496,279, issued on Dec. 16, was assigned to The Johns Hopkins University (Baltimore).

"Nanoparticles for drug delivery to brain" was invented by Jung Soo Suk (Baltimore), Karina Negron (Baltimore) and Justin Hanes (Baltimore).

According to the abstract* released by the U.S. Patent & Trademark Office: "Non-adhesive brain-permeable nanoparticles as large as 200 nm can diffuse rapidly in the brain ECS preferably made entirely of generally recognized as safe (GRAS) materials having neutral surface charge are described. Synergistic improvement of therapeutic distribution enabled by these non-adhesive, brain-permeable nanoparticles and osmosis-driven brain extracellular matrix (ECM) modula...