US Patent Issued to The Johns Hopkins University, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences on Oct. 6 for "Glucose triptolide conjugates and uses thereof" (Chinese, American Inventors)

ALEXANDRIA, Va., Oct. 6 -- United States Patent no. 12,753,200, issued on Oct. 6, was assigned to The Johns Hopkins University (Baltimore) and Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (Shanghai).

"Glucose triptolide conjugates and uses thereof" was invented by Jun O. Liu (Baltimore), Emmanuel Datan (Baltimore), Martin Gilbert Pomper (Baltimore), Il Minn (Baltimore), Peng Xu (Shanghai) and Biao Yu (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "A major hurdle in the treatment of cancer is chemoresistance induced under hypoxia that is characteristic of tumor microenvironment. Triptolide, a potent inhibitor of eukaryotic transcription, possesses potent antitumor activity. Ho...