US Patent Issued to The J. David Gladstone Institutes, The Regents of the University of California on Feb. 10 for "Methods for treating APOE4/4-associated disorders" (California Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,544,348, issued on Feb. 10, was assigned to The J. David Gladstone Institutes (San Francisco) and The Regents of the University of California (Oakland, Calif.).

"Methods for treating APOE4/4-associated disorders" was invented by Yadong Huang (Daville, Calif.), Alice Taubes (San Francisco), Phil Nova (San Francisco) and Marina Sirota (San Francisco).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides methods of treating Alzheimer's Disease (AD) and rescuing cognitive deficits associated with AD in a subject having an apoE4/4 genotype, by administering a therapeutically effective amount of the loop-diuretic bumetanide to the subj...