US Patent Issued to The General Hospital on May 26 for "Prodrugs with a tridentate self-immolative linker" (Austrian, American Inventors)

ALEXANDRIA, Va., May 26 -- United States Patent no. 12,636,373, issued on May 26, was assigned to The General Hospital Corp. (Boston).

"Prodrugs with a tridentate self-immolative linker" was invented by Miles A. Miller (Medford, Mass.), Ralph Weissleder (Peabody, Mass.) and Hannes Mikula (Pixendorf, Austria).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, n, m, p, X, T, TR, and D are as described herein, that is a prodrug that can, for example, be encapsulated in a particle, administered to a subject, and its drug payload released by means of an uncaging reaction. Methods of using these compounds to treat ...