ALEXANDRIA, Va., June 16 -- United States Patent no. 12,653,911, issued on June 16, was assigned to The Brigham And Women's Hospital Inc. (Boston).

"Stimuli-responsive nanoparticles for biomedical applications" was invented by Xiaoding Xu (Boston), Jinjun Shi (Boston) and Omid C. Farokhzad (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Stimuli-responsive NPs with excellent stability, high loading efficiency, encapsulation of multiple agents, targeting to certain cells, tissues or organs of the body, can be used as delivery tools. These NPs contain a hydrophobic inner core and hydrophilic outer shell, which endows them with high stability and the ability to load therapeutic agents with high encapsulat...