ALEXANDRIA, Va., March 31 -- United States Patent no. 12,590,086, issued on March 31, was assigned to Takeda Pharmaceutical Co. Ltd. (Osaka, Japan).

"3-((1H-pyrazol-4-yl)methyl)-6'-(phenyl)-2H-(1,2'-bipyridin)-2-one derivatives and related compounds as GPR139 antagonists for use in a method of treatment of e.g. depression" was invented by Tomoaki Hasui (Fujisawa, Japan), Satoshi Mikami (Fujisawa, Japan), Toru Yamashita (Fujisawa, Japan), Shinji Nakamura (Fujisawa, Japan), Shinji Morimoto (Fujisawa, Japan), Toshihiro Imaeda (Fujisawa, Japan), Kazuaki Takami (Fujisawa, Japan), Masaki Daini (Fujisawa, Japan), Hiroyuki Kakei (Fujisawa, Japan), Minoru Nakamura (Fujisawa, Japan), Fumie Yamaguchi (Fujisawa, Japan), Chunxiang Wang (Fujisawa, Japan...