ALEXANDRIA, Va., Sept. 8 -- United States Patent no. 12,728,130, issued on Sept. 8, was assigned to TAIHO PHARMACEUTICAL Co. LTD. (Tokyo).
"Method for treating cancer patients with severe renal impairment" was invented by Kenichiro Yoshida (Tsukuba, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method for treating cancer in patients with creatinine clearance of 15 mL/min or more and less than 30 mL/min, including dividing a combination drug containing Alpha,Alpha,Alpha-trifluorothymidine (FTD) and 5-chloro-6-[(2-iminopyrrolidine-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione hydrochloride in a molar ratio of 1:0.5, in a dose of 30 to 40 mg/m2/day as FTD-equivalent, into two to four times a day, and orally ...