US Patent Issued to SyntheX on Sept. 29 for "Selective degradation of proteins" (California Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,747,515, issued on Sept. 29, was assigned to SyntheX Inc. (San Francisco).

"Selective degradation of proteins" was invented by Charly Chahwan (San Francisco) and Maria Soloveychik (San Francisco).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides methods to identify peptides and small molecule moieties that are able to functionally bridge an interaction between a target protein and an E3 ubiquitin ligase to mediate the degradation of the target protein. Some moieties can degrade specific target variants, but not others. The moieties create a neosubstrate for an E3 ligase of interest. The methods described enable generation of...