ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,552,774, issued on Feb. 17, was assigned to SUZHOU FUSHILAI PHARMACEUTICAL Co. LTD (Suzhou, China).
"Method for preparing pyrotinib" was invented by Xiaohong Zhang (Suzhou, China), Yongxing Wang (Suzhou, China), Xiaotong Sun (Suzhou, China) and Qiuyue Han (Suzhou, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method for preparing pyrotinib, which belongs to the technical field of chemical synthesis of medicines. The method comprises the following steps: 1. preparing R,E-N-(-2-hydroxy-4-nitrophenyl)-3-(-1-methylpyrrolidin-2-yl)acrylamide; 2. preparing (R,E)-N-(2-ethoxy-4-nitrophenyl)-3-(1-methylpyrrolidin-2-yl)acrylamide; 3. preparing (R,E)-N-(4...