ALEXANDRIA, Va., July 21 -- United States Patent no. 12,686,848, issued on July 21, was assigned to SPHEBIO Co. LTD. (Pohang-si, South Korea).

"Method for preparing cellular spheroid and method for producing extracellular vesicles by using cellular spheroid prepared by such method" was invented by Keunsun Ahn (Pohang-si, South Korea).

According to the abstract* released by the U.S. Patent & Trademark Office: "Proposed is a method of producing extracellular vesicles by using a cellular spheroid prepared by: preparing a first composition comprising cells and a heat-sensitive hydrogel dissolved in an ionic solution; dispensing the first composition drop by drop into a second hydrogel; forming core-shell structures by causing a reaction betwe...