US Patent Issued to Simcha IL-18, Yale University on March 24 for "Interleukin-18 variants and methods of use" (Connecticut Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,582,701, issued on March 24, was assigned to Simcha IL-18 Inc. (New Haven, Conn.) and Yale University (New Haven, Conn.).

"Interleukin-18 variants and methods of use" was invented by Aaron Ring (Milford, Conn.) and Tom Boone (New Haven, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides compositions and methods comprising stabilized IL-18 polypeptides for use in therapeutic and non-therapeutic applications. In some cases, the stabilized IL-18 proteins provide IL-18 signaling activity even in the presence of an inhibitory molecule such as IL-18BP. Also provide are methods of administration and methods for making active ...