US Patent Issued to Simcere Innovation on June 2 for "Armed dual CAR-T compositions and methods for cancer immunotherapy" (Massachusetts Inventors)

ALEXANDRIA, Va., June 2 -- United States Patent no. 12,643,933, issued on June 2, was assigned to Simcere Innovation Inc. (Cambridge, Mass.).

"Armed dual CAR-T compositions and methods for cancer immunotherapy" was invented by Shengjun Ren (Chestnut Hill, Mass.) and Hanan Dahche (Wilmington, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure provides, in various embodiments, polynucleotides and vectors comprising sequences encoding a mono-specific or a bi-specific CAR that is capable of binding to a first TAA, or a T-cell engager that is capable of binding to CD3 and a second TAA, or a combination thereof. The disclosure also provides, in various embodiments, T lymphocytes comprising one or ...