US Patent Issued to SHANGHAI MIRAN BIOTECH on Sept. 22 for "Fluorescent cross-linked RNase H mutant conjugate, miRNA combination and application thereof" (Chinese Inventor)

ALEXANDRIA, Va., Sept. 24 -- United States Patent no. 12,742,207, issued on Sept. 22, was assigned to SHANGHAI MIRAN BIOTECH Co. LTD. (Shanghai).

"Fluorescent cross-linked RNase H mutant conjugate, miRNA combination and application thereof" was invented by Yiran Wang (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "A fluorescent cross-linked RNase H mutant conjugate, a miRNA combination and an application thereof. The fluorescent cross-linked RNase H mutant conjugate (i) is as represented by RNase Hv-(Lx-SH-F)n or (ii) comprises an RNase Hv-Lx-ligand receptor-F, wherein the ligand can bind to the receptor, RNase Hv is an RNase H mutant, which can bind to RNA or RNA-DNA hybrid strands, but cannot clea...