US Patent Issued to Retinal Solutions on Dec. 2 for "Norrin induced expression of genes and use thereof to treat disease" (Michigan Inventors)

ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,485,158, issued on Dec. 2, was assigned to Retinal Solutions LLC (Ann Arbor, Mich.).

"Norrin induced expression of genes and use thereof to treat disease" was invented by Wendelin Dailey (Ann Arbor, Mich.), Kenneth Mitton (Ann Arbor, Mich.), Kimberly Drenser (Ann Arbor, Mich.) and Michael T. Trese (Ann Arbor, Mich.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method is provided to increase the expression of the genes CASP3 and THBD; and decrease the expression of the genes COL18A1, CPB2, NPR1, OCLN, BMP2, CLCL6, IL12B, SELPLG, CX3CL1, CASP3, THBD, COL18A1, CPB2, NPR1, CLDN5, CLD3, PIGF, BDNF, CNTF, VEGF-A, CAM-1, PGF, FOX-01, FOX-04, PDGFB, TGFA, HGF...