US Patent Issued to Research Corporation Technologies, on July 15 for "Pichia pastoris strains for producing predominantly homogeneous glycan structure" (Arizona, California Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,359,211, issued on July 15, was assigned to Research Corporation Technologies, Inc. (Tucson, Ariz.).

"Pichia pastoris strains for producing predominantly homogeneous glycan structure" was invented by Kurt R. Gehlsen (Tucson, Ariz.) and Thomas G. Chappell (San Marcos, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are novel Pichia pastoris strains for expression of exogenous proteins with substantially homogeneous N-glycans. The strains are genetically engineered to include a mutant OCH1 allele which is transcribed into an mRNA coding for a mutant OCH1 gene product (i.e., Alpha-1,6-mannosyltransferase, or "OCH1 protein"). The muta...