ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,510,522, issued on Dec. 30, was assigned to REMEGEN Co. LTD. (Yantai, China).
"Method for detecting DTPA content in ADC by LC-MS/MS" was invented by Xuejing Yao (Yantai, China), Fangfang Sun (Yantai, China), Wenlong Sun (Yantai, China) and Guiping Qi (Yantai, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to a method for detecting DTPA content in ADC by LC-MS/MS. The samples are derivatized with Fe3+ under a weak alkaline derivatization condition, and a weak alkaline mobile phase is used, without need for addition of ion-pair reagents. This method has the characteristics of high efficiency, high stability and strong ...