US Patent Issued to Regeneron Pharmaceuticals on Feb. 10 for "Mice that make heavy chain antibodies" (New York, California Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,543,713, issued on Feb. 10, was assigned to Regeneron Pharmaceuticals Inc. (Tarrytown, N.Y.).

"Mice that make heavy chain antibodies" was invented by Lynn Macdonald (Harrison, N.Y.), Sean Stevens (Del Mar, Calif.) and Andrew J. Murphy (Croton-on-Hudson, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion in an immunoglobulin constant region CH1 gene (optionally a deletion in a hinge region) of an IgG, IgA, IgD, and/or IgE, and wherein the mouse is capable of expressing a functional IgM. Genetic...