US Patent Issued to Regeneron Pharmaceuticals on Dec. 30 for "Antibodies comprising chimeric constant domains" (New York Inventors)

ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,509,514, issued on Dec. 30, was assigned to Regeneron Pharmaceuticals Inc. (Tarrytown, N.Y.).

"Antibodies comprising chimeric constant domains" was invented by Samuel Davis (New York), Eric Smith (New York) and Supriya Patel (Mamaroneck, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion...