US Patent Issued to RaQualia Pharma on July 7 for "Pyrimidin-4(3H)-one derivatives as TRPV4 antagonists" (Japanese Inventors)

ALEXANDRIA, Va., July 7 -- United States Patent no. 12,673,946, issued on July 7, was assigned to RaQualia Pharma Inc. (Aichi, Japan).

"Pyrimidin-4(3H)-one derivatives as TRPV4 antagonists" was invented by Yuji Shishido (Aichi, Japan), Tadashi Inoue (Aichi, Japan), Tatsuya Yamagishi (Aichi, Japan), Kazuo Ando (Aichi, Japan), Yutaka Fukumoto (Aichi, Japan) and Ryohei Magara (Aichi, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "This invention relates to pyrimidin-4(3H)-one derivatives of formula (I),that act as modulators of the TRPV4 receptor. The present invention also relates to processes for the preparation of novel pyrimidin-4(3H)-one derivatives of formula (I) and to their use in the treatment of ...