US Patent Issued to President and Fellows of Harvard College on Sept. 29 for "Multiplex RNA-guided genome engineering" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,747,456, issued on Sept. 29, was assigned to President and Fellows of Harvard College (Cambridge, Mass.).

"Multiplex RNA-guided genome engineering" was invented by George M. Church (Brookline, Mass.) and James Dicarlo (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods of multiplex genome engineering in cells using Cas9 is provided which includes a cycle of steps of introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to the target DNA and which guide the enzyme to the target DNA, wherein the one or more RNAs and the enzyme are members of a co-localization complex for the target DNA, and introducing ...