US Patent Issued to President and Fellows of Harvard College on Sept. 1 for "Stabilized trioxacarcin antibody drug conjugates and uses thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 1 -- United States Patent no. 12,721,904, issued on Sept. 1, was assigned to President and Fellows of Harvard College (Cambridge, Mass.).

"Stabilized trioxacarcin antibody drug conjugates and uses thereof" was invented by Andrew G. Myers (Cambridge, Mass.) and Ethan L. Magno (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are antibody drug conjugates of Formula (I): G-R7(I) and pharmaceutically acceptable salts thereof, wherein G is a molecular payload; and R7 is -L-A-B, wherein L is a linking group, A is a conjugating group, and B is an antibody or antibody fragment. Also provided are methods of preparing the antibody-drug conjugates, pharmaceutically ...