US Patent Issued to President and Fellows of Harvard College on March 17 for "Orthogonal Cas9 proteins for RNA-guided gene regulation and editing" (Massachusetts, California Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,590, issued on March 17, was assigned to President and Fellows of Harvard College (Cambridge, Mass.).

"Orthogonal Cas9 proteins for RNA-guided gene regulation and editing" was invented by George M. Church (Brookline, Mass.), Kevin M. Esvelt (Auburndale, Mass.) and Prashant G. Mali (La Jolla, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes."

The patent was filed on April 6, 2023, under App...