US Patent Issued to President and Fellows of Harvard College on July 7 for "Method to identify compounds useful to treat dysregulated lipogenesis, diabetes, and related disorders" (Massachusetts Inventors)

ALEXANDRIA, Va., July 7 -- United States Patent no. 12,673,987, issued on July 7, was assigned to President and Fellows of Harvard College.

"Method to identify compounds useful to treat dysregulated lipogenesis, diabetes, and related disorders" was invented by Gokhan S. Hotamisligil (Weston, Mass.) and Kosei Eguchi (Brookline, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are compounds, compositions, and methods of identifying compounds that neutralize the ability of the cannabinoid receptor type-1 (CB1) agonist 2-arachidonylglycerol (2-AG) in complex with its obligate binding partner adipocyte lipid binding protein (aP2) from agonizing CB1 signaling in peripheral tissues. Further prov...