US Patent Issued to Phanes Therapeutics on Sept. 15 for "Bispecific antibodies with alternatively matched interchain cysteines and uses thereof" (California, Illinois Inventors)

ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,735,481, issued on Sept. 15, was assigned to Phanes Therapeutics Inc. (San Diego).

"Bispecific antibodies with alternatively matched interchain cysteines and uses thereof" was invented by Jack Chongyang Li (San Diego), Minghan Wang (San Diego), Hui Zou (Hinsdale, Ill.) and Haiqun Jia (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "Engineered bispecific antibodies with shifted interchain disulfide bond on one arm while maintaining the native interchain disulfide bond on the second arm are described. Also described are anti-CD47/FRAlpha bispecific antibodies and antigen-binding fragments thereof. Also described are nucleic acids encoding the an...