US Patent Issued to PentaBase on Oct. 6 for "Detection of methylation status" (Danish Inventors)

ALEXANDRIA, Va., Oct. 6 -- United States Patent no. 12,753,441, issued on Oct. 6, was assigned to PentaBase ApS (Odense C, Denmark).

"Detection of methylation status" was invented by Kamilla Kolding Bendixen (Odense C, Denmark), Rasmus Koefoed Petersen (Odense C, Denmark) and Ulf Bech Christensen (Odense C, Denmark).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a method for determining epigenetic modification status of at least one nucleotide of interest (NOI) in a target nucleic acid sequence of interest. The invention is based on the finding that certain oligonucleotides comprising hydrophobic nucleotides have significant differences in melting temperature to epigenetically...