ALEXANDRIA, Va., April 15 -- United States Patent no. 12,599,672, issued on April 14, was assigned to PAQ Therapeutics Inc. (Burlington, Mass.).
"KRAS proteolysis targeting chimeras" was invented by Nan Ji (Arlington, Mass.), Hui Qiu (Acton, Mass.) and Ruoxi Lan (Waltham, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are KRAS proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS PROTACs, and methods of making and using the KRAS PROTACs, e.g., to promote degradation of KRAS and/or treat KRAS-associated cancers. In an embodiment, the KRAS PROTAC has the following structural formula:or a pharmaceutically acceptable salt thereof, wherein values for the variables are as...