US Patent Issued to Pacific Biosciences of California on May 12 for "Distinguishing sequences by detecting polymerase dissociation" (California Inventors)

ALEXANDRIA, Va., May 12 -- United States Patent no. 12,624,390, issued on May 12, was assigned to Pacific Biosciences of California Inc. (Menlo Park, Calif.).

"Distinguishing sequences by detecting polymerase dissociation" was invented by Denis Malyshev (San Diego) and Sean Stromberg (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for determining the presence of an allele, including (a) binding a polymerase to a double stranded nucleic acid that includes a primer hybridized to a template, the template including a first allele of a locus; (b) adding a nucleotide to the primer via catalytic activity of the polymerase, thereby producing an extended nucleic acid; (c) dissociating the polymeras...