US Patent Issued to Ospedale San Raffaele, Fondazione Telethon on Oct. 27 for "Permanent epigenetic gene silencing" (Italian Inventors)

ALEXANDRIA, Va., Oct. 27 -- United States Patent no. 12,774,465, issued on Oct. 27, was assigned to Ospedale San Raffaele S.R.L. (Milan) and Fondazione Telethon (Rome).

"Permanent epigenetic gene silencing" was invented by Luigi Naldini (Milan), Angelo Leone Lombardo (Milan), Angelo Amabile (Milan) and Alessandro Migliara (Milan).

According to the abstract* released by the U.S. Patent & Trademark Office: "A product comprising two or more artificial transcription repressors (ATRs), or polynucleotides encoding therefor, selected from groups (a), (b), (c) or (d): (a) an ATR comprising a DNA-binding domain operably linked to a KRAB domain or homologue thereof; (b) an ATR comprising a DNA-binding domain operably linked to a DNMT3A, DNMT3B or D...