ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,558,435, issued on Feb. 24, was assigned to Ospedale San Raffaele S.R.L. (Milan) and Fondazione Telethon ETS (Rome).
"Transient inhibition of p53 in gene therapy" was invented by Pietro Genovese (Milan), Giulia Schiroli (Milan), Luigi Naldini (Milan), Aurelien Jacob (Milan) and Samuele Ferrari (Milan).
According to the abstract* released by the U.S. Patent & Trademark Office: "An agent which promotes homology directed DNA repair for use in haematopoietic stem and/or progenitor cell gene therapy, wherein said haematopoietic stem cells are gene edited. Use of an agent which promotes homology directed DNA repair, for increasing the survival and/or engraftment of gene edited haematopoiet...