US Patent Issued to Ohio State Innovation Foundation on July 15 for "Method for producing therapeutic exosomes from nanoelectroporation and other non-endocytic cell transfection" (Ohio Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,359,188, issued on July 15, was assigned to Ohio State Innovation Foundation (Columbus, Ohio).

"Method for producing therapeutic exosomes from nanoelectroporation and other non-endocytic cell transfection" was invented by Ly James Lee (Columbus, Ohio), Junfeng Shi (Dublin, Ohio) and Zhaogang Yang (Columbus, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "Therapeutic extracellular vesicles (EVs) containing high copies of functional nucleic acids and other biomolecules are produced in large quantities by laying donor cells on a surface of a chip, adding various plasmids, other transfection vectors and their combinations to a buffer on the chip, applyi...