US Patent Issued to Ohio State Innovation Foundation on Dec. 16 for "Cyclic peptidyl inhibitors of CAL-PDZ binding domain" (Ohio Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,496,350, issued on Dec. 16, was assigned to Ohio State Innovation Foundation (Columbus, Ohio).

"Cyclic peptidyl inhibitors of CAL-PDZ binding domain" was invented by Dehua Pei (Columbus, Ohio) and Patrick G. Dougherty (Columbus, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein, in various embodiments, are peptides comprising: (i) a cyclic cell-penetrating peptide sequence (cCPP) and (ii) a CAL-PDZ binding sequence, which is conjugated, directly or indirectly, to an N-terminus of an amino acid in the cCPP, to a C-terminus of an amino acid on the cCPP, or on a side chain of an amino acid in the cCPP. In other embodiments, the peptides ...