ALEXANDRIA, Va., March 24 -- United States Patent no. 12,582,603, issued on March 24, was assigned to NTC S.r.l. (Milan).

"Ophthalmic pharmaceutical composition containing a combination of brinzolamide and brimonidine and method of preparation thereof" was invented by Evangelos Karavas (Pallini, Greece), Efthymios Koutris (Pallini, Greece), Vasiliki Samara (Pallini, Greece), Ioanna Koutri (Pallini, Greece), Anastasia Kalaskani (Pallini, Greece), Andreas Kakouris (Pallini, Greece) and Rumit Rajivbhai Shah (Pallini, Greece).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to an ophthalmic aqueous composition for the decrease of intraocular pressure in patients with ocular hypertensio...