US Patent Issued to NOF on Nov. 3 for "Heterobifunctional monodispersed polyethylene glycol having peptide linker" (Japanese Inventors)

ALEXANDRIA, Va., Nov. 3 -- United States Patent no. 12,779,046, issued on Nov. 3, was assigned to NOF Corp. (Tokyo).

"Heterobifunctional monodispersed polyethylene glycol having peptide linker" was invented by Yuki Matsuno (Kawasaki, Japan), Hiroki Yoshioka (Kawasaki, Japan) and Akira Suzuki (Kawasaki, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "A heterobifunctional monodisperse polyethylene glycol with two adjacent monodisperse polyethylene glycol side chains, in which a peptide linker is degraded by intracellular enzymes to release a drug slowly and effectively mask the hydrophobicity of the drug, and an antibody-drug conjugate in which the antibody and the drug are bound using same is provided. A...