ALEXANDRIA, Va., April 15 -- United States Patent no. 12,600,743, issued on April 14, was assigned to NIPPON SHINYAKU Co. LTD. (Kyoto, Japan).
"Method for producing oligonucleic acid compound" was invented by Junshi Asada (Kyoto, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a method for producing a compound [C] of the general formula [C] by subjecting a compound [A] having a hydroxyl group or a primary or secondary amino group and a compound [B] having a phosphorous atom-containing substituent group of the general formula [1] to a condensation reaction, characterized in that the method is carried out in the presence of at least one reaction accelerator selected from t...