ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,451, issued on Dec. 16, was assigned to NEKONAL SARL (Esch/Alzette, Luxembourg).
"Anti-TIRC7 antigen binding proteins" was invented by Nalan Utku (Munich).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides human T-cell immune response cDNA 7 (TIRC7) antibodies, having improved TIRC7 binding affinity, and/or activity. The TIRC7 antibodies of the invention are generated by mutation of a parent TIRC7 antibody reports most of the humanized candidates, position 43 was Q (Gln, amide). But in the best humanized VH (cAb1466-VH) mutation of position 43 was Q (Gln, amide) to K (Lys, basic) appears to important for successful affinit...