US Patent Issued to National University of Singapore on Dec. 2 for "Method to specifically stimulate survival and expansion of genetically-modified immune cells" (Singaporean, Japanese Inventors)

ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,486,514, issued on Dec. 2, was assigned to National University of Singapore (Singapore).

"Method to specifically stimulate survival and expansion of genetically-modified immune cells" was invented by Natasha Vinanica (Singapore), Arthur Yong (Singapore), Dario Campana (Singapore) and Masaru Imamura (Niigata, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a vector encoding a wildtype or truncated form of erythropoietin receptor (EpoR) to promote T cell survival and proliferation. Specifically, it exemplifies a bicistronic vector that expresses a truncated EpoR with an anti-CD19-41 BB-003Zeta chimeric antigen receptor...