ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,746,253, issued on Sept. 29, was assigned to NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (Tokyo).
"Blood-brain barrier permeable heteroduplex nucleic acid" was invented by Takanori Yokota (Tokyo) and Tetsuya Nagata (Tokyo).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a composition and a method for efficiently delivering a nucleic acid agent to the central nervous system and/or the retina and bringing about antisense effects. Provided is a composition for reducing the expression level of a target transcription product in the central nervous system and/or retina of a subject, the composition includi...