US Patent Issued to National Cerebral and Cardiovascular Center on Feb. 10 for "Antisense nucleic acid targeting PCSK9" (Japanese Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,544,449, issued on Feb. 10, was assigned to National Cerebral and Cardiovascular Center (Osaka, Japan).

"Antisense nucleic acid targeting PCSK9" was invented by Mariko Harada-Shiba (Osaka, Japan), Fumito Wada (Osaka, Japan), Satoshi Obika (Osaka, Japan), Tsuyoshi Yamamoto (Osaka, Japan), Keisuke Tachibana (Osaka, Japan), Tadayuki Kobayashi (Osaka, Japan), Kosuke Ito (Osaka, Japan) and Motoki Sawamura (Osaka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is an oligonucleotide conjugate comprising an oligonucleotide and two or more linearly connected asialoglycoprotein receptor-binding molecules attached to the oligonucleotide, wherein the...