ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,487,240, issued on Dec. 2, was assigned to Nantomics LLC (Culver City, Calif.).
"Tumor HLA mutation versus matched normal HLA" was invented by John Zachary Sanborn (Culver City, Calif.) and Andrew Nguyen (Culver City, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Effectiveness of a neoepitope-based immunotherapeutic composition against a tumor can be increased by predicting the surface presentation of the neoepitope bound to the HLA molecule of the tumor cell. Surface presentation levels of neoepitopes can be predicted by identifying any changes in omics data of the tumor cell that may affect the expression or surface trafficking of the HLA molec...