US Patent Issued to Molecular Templates on May 26 for "De-immunized Shiga toxin a subunit effector polypeptides for applications in mammals" (Texas, New York Inventors)

ALEXANDRIA, Va., May 26 -- United States Patent no. 12,637,495, issued on May 26, was assigned to Molecular Templates Inc. (Austin, Texas).

"De-immunized Shiga toxin a subunit effector polypeptides for applications in mammals" was invented by Eric Poma (New York), Erin Willert (Round Rock, Texas), Garrett Lee Robinson (Austin, Texas), Sangeetha Rajagopalan (Round Rock, Texas) and Brigitte Brieschke (Austin, Texas).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to Shiga toxin effector polypeptides with reduced antigenic and/or immunogenic potential. Immunogenicity can be a limitation for the repeated administration to mammals of proteins and polypeptides derived from Shiga toxins....