US Patent Issued to ModernaTX on July 21 for "Polynucleotides encoding propionyl-CoA carboxylase alpha and beta subunits for the treatment of propionic acidemia" (Massachusetts, New Hampshire Inventors)

ALEXANDRIA, Va., July 21 -- United States Patent no. 12,685,785, issued on July 21, was assigned to ModernaTX Inc. (Cambridge, Mass.).

"Polynucleotides encoding propionyl-CoA carboxylase alpha and beta subunits for the treatment of propionic acidemia" was invented by Lei Jiang (Cambridge, Mass.), Lin Tung Guey (Lexington, Mass.), Paolo G. V. Martini (Boston) and Vladimir Presnyak (Manchester, N.H.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure relates to mRNA therapy for the treatment of propionic acidemia (PA). mRNAs for use in the invention, when administered in vivo, encode human propionyl-CoA carboxylase alpha (PCCA) and/or human propionyl-CoA carboxylase beta (PCCB), and isoforms thereof...