ALEXANDRIA, Va., May 26 -- United States Patent no. 12,637,658, issued on May 26, was assigned to MIE UNIVERSITY (Tsu, Japan).
"Method for gene transfer into gamma-delta type T cell" was invented by Hiroshi Shiku (Tsu, Japan), Yoshihiro Miyahara (Tsu, Japan), Satoshi Okumura (Tsu, Japan), Takuma Kato (Tsu, Japan), Tae Hayashi (Tsu, Japan) and Yoshimasa Tanaka (Nagasaki, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a method for efficiently producing highly pure GammaDeltaT cells introduced with foreign genes by culturing in the presence of IL-7 and IL-15 after stimulating the GammaDeltaT cells with a bisphosphonic acid ester derivative. When a T cell receptor (TCR) or a ...