US Patent Issued to Merck Sharp & Dohme on Sept. 15 for "6,7-dihydro-pyrano[2,3-dpyrimidine inhibitors of KRAS G12C mutant" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,735,425, issued on Sept. 15, was assigned to Merck Sharp & Dohme LLC (Rahway, N.J.).

"6,7-dihydro-pyrano[2,3-dpyrimidine inhibitors of KRAS G12C mutant" was invented by Yongxin Han (Needham, Mass.), Elisabeth Hennessy (Weston, Mass.), Andrew J. Hoover (Framingham, Mass.), Jesus Moreno (Dorchester Center, Mass.) and Uma Swaminathan (Auburndale, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, CA, R1, R2a, and R2b are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten r...