ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,485,113, issued on Dec. 2, was assigned to MEDCURIUS INC. (Shanghai).

"Pharmaceutical use of (e)-3-arylheterocyclylprop-2-enoic acid derivatives" was invented by Xuyang Zhao (Shanghai) and Jun Wen (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present application relates to the pharmaceutical use of a class of (E)-3-arylheterocyclyl prop-2-enoic acid derivatives. Such compounds are a class of new Nrf2 activators, which effectively activate Nrf2 signaling pathway to produce the effects of resisting oxidative stress, resisting neuritis, and enhancing mitochondrial function and biogenesis, thereby protecting nerve cells, and same can be used t...