US Patent Issued to Ludwig Institute for Cancer Research, The Wistar Institute on Sept. 29 for "Immune cells with enhanced cytotoxicity and methods of use thereof" (Pennsylvania Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,747,443, issued on Sept. 29, was assigned to Ludwig Institute for Cancer Research Ltd (New York) and The Wistar Institute (Philadelphia).

"Immune cells with enhanced cytotoxicity and methods of use thereof" was invented by Zandra Walton (Philadelphia), Zachary Stine (Philadelphia), Yaoyu Gong (Philadelphia) and Chi V. Dang (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure provides methods for enhancing antitumor cytotoxicity of immune cells by introducing to the immune cells a genetic modification that comprises overexpression of RHEB or a functional fragment thereof, overexpression of LAMP 1-RHEB or a functional fragment the...