ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,303, issued on March 17, was assigned to L&L Bio Co. Ltd., Ningbo, China (Zhejiang, China).

"SIRPAlpha-targeting antibody or antigen binding fragment thereof, and preparation and application thereof" was invented by Jiajian Liu (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed is a SIRPAlpha-targeting antibody or an antigen-binding fragment thereof, comprising a light chain variable region and/or a heavy chain variable region. The antibody or the antigen-binding fragment thereof binds to human SIRPAlpha-V1 and human SIRPAlpha-V2, but weakly or does not bind to human SIRPBeta and SIRPGamma, does not bind to human T cells, and has th...