ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,545,659, issued on Feb. 10, was assigned to Kymera Therapeutics Inc. (Watertown, Mass.).
"IRAK degraders and uses thereof" was invented by Nello Mainolfi (Belmont, Mass.), Nan Ji (Arlington, Mass.), Matthew M. Weiss (Boston), Xiaozhang Zheng (Lexington, Mass.), Yi Zhang (Belmont, Mass.) and Paul R. Fleming (Lexington, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compo...