ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,548,650, issued on Feb. 10, was assigned to KONINKLIJKE PHILIPS N.V. (Eindhoven, Netherlands).

"Methods and systems for performing dose titration" was invented by Benjamin Irwin Shelly (Pittsburgh) and William Gaussa (Jeannette, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides a computer-implemented method for controlling a dose titration of a medicament to be provided to a subject for treating obstructive sleep apnea. The method includes obtaining a dose level of a previous dose of the medicament, the previous dose having been provided to the subject and obtaining a medicament efficacy measure based on a response of the subject...